The cheapest times to fly from EYW to DSM are

  • April 9th to August 5th (except the weeks of April 16th, May 14th, June 11th, and July 2nd)
  • October 15th to October 28th
  • December 24th to February 25th (except the weeks of January 29th and February 12th)

based on data collected exclusively by Champion Traveler across tens of millions of flights. Among all the dates above, the very cheapest time to fly from EYW to DSM is mid January. Prices can be as high as $1171 for Sunday flights during late November to early December, or as low as $317 for Tuesday flights around mid January.


When to Fly to Des Moines

Flying from Key West, FL (EYW) to Des Moines, IA (DSM) will usually cost between $377 to $753 per person if booking more than four weeks in advance. On average the very cheapest time to fly is mid January with an average ticket price of $410. Due to high demand the most expensive time to fly is late November to early December, with an average price of $684. Planning your trip to low-cost times can easily save you $274 on economy flights and even more on first-class flights. Generally, any price below $495 can be considered a good price for a round-trip EYW to DSM flight.

See below for a graph of average weekly prices for the EYW to DSM route. All prices are for round-trip tickets in USD.

EYW to DSM Flight Prices

Compared to other flights, the EYW to DSM flight is much cheaper than the average and costs less than the average flight leaving from Key West. The average price per mile (for a direct flight) is $0.23, which is below average.


Flight Prices by Day of the Week

Tuesday is usually the cheapest day to depart and return on this flight. Sundays are the most expensive days to fly out or take a return trip. Selecting flights on the least expensive days could save you up to $222 (35%) on this flight.

Departing prices are for round-trip flights returning on the day of departure. For example, a flight departing on Tuesday and returning a week later will cost an average of $402. Return trip prices are from the DSM to EYW flight, and often highlight the quality of our data in showing the same trend.

Departing Prices by Day

Departure Day Prices

Return Trip Prices by Day

Return Day Prices


Nonstop Flights and Layovers

Travelers looking to fly from EYW to DSM can generally find a 1-layover flight. Because there is not usually a direct flight option the real-world direct flight time of 3 hour 25 minutes may not be realistic.


Flight Hacking EYW to DSM

Flight hacking is when you book two tickets instead of a layover, sometimes with different airlines. You will need to either bring only a carry-on bag (highly recommended) or leave yourself plenty of time to go through security again. Flight hacking is completely allowed, but airlines don’t always tell you the cheapest way to get from EYW to DSM — but Champion Traveler does!

Hack #1: Fort Lauderdale, FL (EYW > FLL > DSM)

  • Price for both tickets: $462
  • Average savings: $33 (6.67%)

See EYW to FLL flights


Flight Questions Answered

Still have questions about flying from EYW to DSM? We’ve got answers.

Which airlines fly this route?

You can find 4 major airlines flying this route most often: American, Delta, SAS, United, and potentially more during busy seasons.

How far away is it from Des Moines International Airport to Key West International Airport?

The distance between the two airports is roughly 1357 miles or 2184 kilometers.

How long does it take to fly from EYW to DSM?

The real-world flight time for a nonstop EYW to DSM flight is about 3 hour 25 minutes.

How many flights go between Key West, FL and Des Moines, IA?

It depends on the day of the week and the date, but a typical day might have around 20 available flights from EYW to DSM.


Airport Location Info


Departing Airport

Origination codeEYW
Origination airport nameKey West International Airport
CityKey West, FL
Countrythe United States

Return Airport

Destination codeDSM
Destination airport nameDes Moines International Airport
CityDes Moines, IA
Countrythe United States


Other Resources

Please note that while we’ve worked hard to analyzed tens of millions of flights to get you this data, we do not calculate current live prices or guarantee pricing. Please see our partners using the links above for current offers.